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Herein, a novel [Rh]2-catalyzed three-component reaction of readily accessible indoles, diazo compounds, and allylic compounds is developed via a relay carbene-induced C-H functionalization and allylic alkylation process, affording diverse C3-substituted… Click to show full abstract
Herein, a novel [Rh]2-catalyzed three-component reaction of readily accessible indoles, diazo compounds, and allylic compounds is developed via a relay carbene-induced C-H functionalization and allylic alkylation process, affording diverse C3-substituted indoles bearing all-carbon quaternary centers in good yields with high atom and step economy. Moreover, good enantioselective control is achieved using a (-)-DIOP type ligand, thus providing an efficient method for constructing enantioenriched indole derivatives bearing an all-carbon quaternary stereocenter.
Journal Title: Organic letters
Year Published: 2022
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