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Gold-catalyzed reactions between sulfenamides and terminal alkynes proceeded via cis-insertion of alkynes into the N-S bond in sulfenamides, affording the corresponding β-sulfenylenamines in yields up to 90%. Mechanistic studies revealed… Click to show full abstract
Gold-catalyzed reactions between sulfenamides and terminal alkynes proceeded via cis-insertion of alkynes into the N-S bond in sulfenamides, affording the corresponding β-sulfenylenamines in yields up to 90%. Mechanistic studies revealed that the reactions proceeded via nucleophilic attack of the sulfenamide nitrogen atom on the π-activated alkyne, followed by tosylate-assisted intermolecular transfer of the sulfenyl group.
Keywords:
bond sulfenamides;
catalyzed intermolecular;
insertion;
gold catalyzed;
intermolecular alkyne
Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!