A mild and convenient strategy has been developed for the para-selective chalcogenation of anilide scaffolds via C-H bond functionalization. This methodology employs one of the most earth-abundant and inexpensive Cu(II)… Click to show full abstract
A mild and convenient strategy has been developed for the para-selective chalcogenation of anilide scaffolds via C-H bond functionalization. This methodology employs one of the most earth-abundant and inexpensive Cu(II) catalysts and a commercially available simple aryl chalcogen source without any complex directing template, exogenous ligand, acid/base, oxidant, or other additives. The key feature of this methodology is an impressive regioselectivity along with a wide range of functional group tolerance with good to excellent yields under aerobic conditions.
Journal Title: Organic letters
Year Published: 2023
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