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Palladium-Catalyzed Oxidative Annulation Leading to Substituted Pyrrolo[3,2,1-jk]carbazoles by Sequential C-N and C-C Bond Formation.

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A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-jk]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-jk]carbazoles from simple… Click to show full abstract

A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-jk]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-jk]carbazoles from simple carbazoles. In situ synthesis of propargyl alcohols from simple, cheap, and easily accessible ketones has also been developed during the one-pot synthesis of [3,2,1-jk]carbazoles.

Keywords: catalyzed oxidative; palladium catalyzed; annulation; leading substituted; annulation leading; oxidative annulation

Journal Title: Organic letters
Year Published: 2023

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