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A nickel-catalyzed direct reaction of allylic alcohols with benzyl nitrile derivatives has been developed. The method provides an efficient route for the synthesis of nitriles bearing an α-tertiary or quaternary… Click to show full abstract
A nickel-catalyzed direct reaction of allylic alcohols with benzyl nitrile derivatives has been developed. The method provides an efficient route for the synthesis of nitriles bearing an α-tertiary or quaternary carbon center in good to excellent yields with high regioselectivity, wide substrate scope, and functional group compatibility. BSA was identified as the effective additive for facilitating the coupling process mainly for alkyl allylic alcohols.
Keywords:
direct substitution;
nickel catalyzed;
allylic alcohols;
catalyzed direct;
tertiary quaternary
Journal Title: Organic letters
Year Published: 2023
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!