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The N-functionalization of free sulfoximines is an important approach to modifying their chemical and biological properties for downstream applications. Here, we report a rhodium-catalyzed N-allylation of free sulfoximines (═NH) with… Click to show full abstract
The N-functionalization of free sulfoximines is an important approach to modifying their chemical and biological properties for downstream applications. Here, we report a rhodium-catalyzed N-allylation of free sulfoximines (═NH) with allenes under mild conditions. The redox-neutral and base-free process enables chemo- and enantioselective γ-hydroamination of allenes and gem-difluoroallenes. Synthetic applications of sulfoximine products obtained thereof have been demonstrated.
Keywords:
allylation;
rhodium catalyzed;
catalyzed enantioselective;
allylation sulfoximines;
enantioselective allylation
Journal Title: Organic letters
Year Published: 2023
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!