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A novel Pd-catalyzed enantioselective aminochlorination of alkenes via a 6-endo cyclization is reported herein, which provides easy access to a wide array of structurally diverse 3-chloropiperidines in good yields with… Click to show full abstract
A novel Pd-catalyzed enantioselective aminochlorination of alkenes via a 6-endo cyclization is reported herein, which provides easy access to a wide array of structurally diverse 3-chloropiperidines in good yields with excellent enantioselectivities. Notably, both an electrophilic chlorination reagent (NCS) and the sterically bulky chiral pyridinyl-oxazoline (Pyox) ligand are crucial to the successful reaction.
Keywords:
aminochlorination unactivated;
palladium catalyzed;
asymmetric palladium;
aminochlorination;
catalyzed aminochlorination;
unactivated alkenes
Journal Title: Organic letters
Year Published: 2023
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!