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Transamination of Aromatic Aldehydes to Primary Arylmethylamines.

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In the presence of 2-amino-2-phenylpropanoate salt (2a or 2e) as the amine source, aromatic aldehydes underwent decarboxylative transamination under very mild conditions to produce a variety of arylmethylamines in 44-99%… Click to show full abstract

In the presence of 2-amino-2-phenylpropanoate salt (2a or 2e) as the amine source, aromatic aldehydes underwent decarboxylative transamination under very mild conditions to produce a variety of arylmethylamines in 44-99% yields. The work has provided an efficient new method for the synthesis of primary arylmethylamines.

Keywords: aldehydes primary; transamination aromatic; primary arylmethylamines; aromatic aldehydes

Journal Title: Organic letters
Year Published: 2023

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