A Mn(I)-catalyzed site-selective nondirected C3-maleimidation of quinoxaline is established. Herein, the electrophilic C3-metalation precedes over the o-directed strategy to access diversely substituted quinoxaline-appended succinimides. The products undergo PIFA-promoted C(sp2)-C(sp3) spirocyclization… Click to show full abstract
A Mn(I)-catalyzed site-selective nondirected C3-maleimidation of quinoxaline is established. Herein, the electrophilic C3-metalation precedes over the o-directed strategy to access diversely substituted quinoxaline-appended succinimides. The products undergo PIFA-promoted C(sp2)-C(sp3) spirocyclization via π-electrons drifting from aryls and Selectfluor-mediated dehydrogenation of succinimide at room temperature.
Keywords:
catalyzed preferential;
maleimidation quinoxaline;
spirocyclization;
quinoxaline;
dehydrogenation
Journal Title: Organic letters
Year Published: 2023
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Journal Title: Organic letters
Year Published: 2023
Link to full text (if available)
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recommendations!