An efficient synthesis of quinoxaline-fused aza-bicyclo[2.1.1]hexanes bearing multiple quaternary carbon centers via the intermolecular [2π+2σ] cycloaddition of bicyclo[1.1.0]butanes and quinoxalin-2(1H)-ones, facilitated by Lewis acid catalysis, is presented. This reaction is… Click to show full abstract
An efficient synthesis of quinoxaline-fused aza-bicyclo[2.1.1]hexanes bearing multiple quaternary carbon centers via the intermolecular [2π+2σ] cycloaddition of bicyclo[1.1.0]butanes and quinoxalin-2(1H)-ones, facilitated by Lewis acid catalysis, is presented. This reaction is carried out under mild conditions and exhibits a broad substrate scope and excellent functional group tolerance.
Keywords:
quinoxalin ones;
bicyclo;
quinoxaline fused;
fused aza;
aza bicyclo;
bicyclo hexanes
Journal Title: Organic letters
Year Published: 2024
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Journal Title: Organic letters
Year Published: 2024
Link to full text (if available)
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recommendations!