A three-component cascade boronation-dearomatization reaction of alkenes, a diboron compound, and a pyridinium salt is diclosed, affording chiral boron-containing 1,4-dihyropyridines in high yields (≤98%) and diastereoselectivity (≤10:1 dr), along with… Click to show full abstract
A three-component cascade boronation-dearomatization reaction of alkenes, a diboron compound, and a pyridinium salt is diclosed, affording chiral boron-containing 1,4-dihyropyridines in high yields (≤98%) and diastereoselectivity (≤10:1 dr), along with excellent enantioselectivity (typically >99% ee). The catalytic system performs efficiently at low catalyst loadings (1 mol %) and was tested with >50 examples, including some biologically active molecules.
Keywords:
boronation dearomatization;
three component;
dearomatization reaction;
component cascade;
cascade boronation;
chiral boron
Journal Title: Organic letters
Year Published: 2025
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Journal Title: Organic letters
Year Published: 2025
Link to full text (if available)
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recommendations!