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Annulation of Enyne-Amide with Enaminone Enables Divergent Synthesis of Furo[2,3-b]pyridine Derivatives.

A wide range of furo[2,3-b]pyridine and furo[2,3-b]dihydropyridine derivatives, which might be of value in biomedicinal chemistry and materials science, are divergently delivered through Ag(I)-catalyzed tandem cycloisomerization/cyclization reactions between enyne-amides and… Click to show full abstract

A wide range of furo[2,3-b]pyridine and furo[2,3-b]dihydropyridine derivatives, which might be of value in biomedicinal chemistry and materials science, are divergently delivered through Ag(I)-catalyzed tandem cycloisomerization/cyclization reactions between enyne-amides and enaminones just by tuning the reaction conditions. The products could be conveniently transformed into various derivatives.

Keywords: enyne amide; annulation enyne; pyridine; furo pyridine; amide enaminone

Journal Title: Organic letters
Year Published: 2025

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