Chizhiaroterpenoids A-C (1-3), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (1), 6/6/6/6/7 (2), and 6/6/6/5/6 (3) ring systems, were isolated from Ganoderma lucidum. Their biosynthetic pathways were proposed.… Click to show full abstract
Chizhiaroterpenoids A-C (1-3), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (1), 6/6/6/6/7 (2), and 6/6/6/5/6 (3) ring systems, were isolated from Ganoderma lucidum. Their biosynthetic pathways were proposed. 1 and 3 suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice. Additionally, 2 and 3 inhibited cancer-associated fibroblast-mediated extracellular matrix remodeling by modulating laminin, suggesting potential anti-breast cancer effects.
Journal Title: Organic letters
Year Published: 2025
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