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α-l-Threofuranosyl nucleoside 3'-triphosphates (tNTPs) bearing the four genetic bases adenine (A), cytosine (C), guanine (G), and thymine (T) were synthesized on a gram scale using an iterative phosphorylation strategy that… Click to show full abstract
α-l-Threofuranosyl nucleoside 3'-triphosphates (tNTPs) bearing the four genetic bases adenine (A), cytosine (C), guanine (G), and thymine (T) were synthesized on a gram scale using an iterative phosphorylation strategy that avoids the need for tedious HPLC purification. This new synthetic procedure greatly increases the scale on which tNTP substrates can be produced for polymerase-mediated TNA synthesis studies.
Keywords:
gram scale;
using iterative;
iterative phosphorylation;
phosphorylation strategy
Journal Title: Organic letters
Year Published: 2017
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!