A general, transition-metal-free, one-pot, domino Michael-SNAr or AdNE substitution protocol was devised for spiroannulation of oxindoles with ortho-bromoaryl ynones, β-bromoalkenyl ynones, and β-bromoalkenyl enones in a convenient and efficient manner.… Click to show full abstract
A general, transition-metal-free, one-pot, domino Michael-SNAr or AdNE substitution protocol was devised for spiroannulation of oxindoles with ortho-bromoaryl ynones, β-bromoalkenyl ynones, and β-bromoalkenyl enones in a convenient and efficient manner. As an application, a short synthesis of tetracyclic alkaloid spindomycin B was accomplished.
Keywords:
stitching oxindoles;
domino;
short synthesis;
application short;
spindomycin
Journal Title: Organic letters
Year Published: 2017
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Journal Title: Organic letters
Year Published: 2017
Link to full text (if available)
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recommendations!