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Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes.

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Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides… Click to show full abstract

Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides as reactive intermediates.

Keywords: annulation amino; annulation; amino acids; decarboxylative annulation; acids ketoaldehydes

Journal Title: Organic letters
Year Published: 2018

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