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Matteson Homologation-Based Total Synthesis of Lagunamide A.

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Matteson homologation was found to be an excellent tool for the synthesis of the polyketide fragment of lagunamide A. Starting from a chiral boronic ester, a central building block containing… Click to show full abstract

Matteson homologation was found to be an excellent tool for the synthesis of the polyketide fragment of lagunamide A. Starting from a chiral boronic ester, a central building block containing all stereogenic centers of the polyketide chain was synthesized via six iterative Matteson homologation steps.

Keywords: based total; matteson homologation; homologation; homologation based; synthesis

Journal Title: Organic letters
Year Published: 2018

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