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Visible-Light-Promoted Oxidative Amidation of Bromoalkynes with Anilines: An Approach to α-Ketoamides.

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A convenient and practical synthetic route to α-ketoamides from bromoalkynes and anilines through phototriggered organic transformations via a C-N cross-coupling and an oxidation of C≡C was developed. The reaction could… Click to show full abstract

A convenient and practical synthetic route to α-ketoamides from bromoalkynes and anilines through phototriggered organic transformations via a C-N cross-coupling and an oxidation of C≡C was developed. The reaction could be furnished without an external photocatalyst at ambient conditions, and a wide range of α-ketoamides were obtained in good yields.

Keywords: oxidative amidation; visible light; promoted oxidative; bromoalkynes anilines; amidation bromoalkynes; light promoted

Journal Title: Organic letters
Year Published: 2018

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