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A tandem Cu(I)-catalyzed conjugate addition of Kharasch reagents/diastereoselective protonation of ( E)-α-trialkylsilyl-β-alkyl(aryl)-α,β-unsaturated esters afforded the saturated products with d.r. values of >20:1 favoring the anti-diastereomer in modest to excellent isolated… Click to show full abstract
A tandem Cu(I)-catalyzed conjugate addition of Kharasch reagents/diastereoselective protonation of ( E)-α-trialkylsilyl-β-alkyl(aryl)-α,β-unsaturated esters afforded the saturated products with d.r. values of >20:1 favoring the anti-diastereomer in modest to excellent isolated yields.
Keywords:
diastereoselective protonation;
conjugate addition;
catalyzed conjugate;
trialkylsilyl alkyl;
alkyl aryl;
protonation trialkylsilyl
Journal Title: Organic letters
Year Published: 2018
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!