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The first general protocol for the synthesis of 1,3-benzothiazepine derivatives was established. With the aid of bench-stable hypervalent iodine promoter fluoro-HTIB, these seven-membered heterocycles can be rapidly synthesized from readily… Click to show full abstract
The first general protocol for the synthesis of 1,3-benzothiazepine derivatives was established. With the aid of bench-stable hypervalent iodine promoter fluoro-HTIB, these seven-membered heterocycles can be rapidly synthesized from readily available thioamides under air atmosphere and metal-free conditions. The transformation can be completed within 1 min at room temperature and features a broad substrate scope.
Keywords:
free conditions;
benzothiazepines direct;
construction benzothiazepines;
fast construction;
direct intramolecular;
metal free
Journal Title: Organic letters
Year Published: 2018
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Journal Title: Organic letters
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!