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In(OTf)3-Catalyzed Cascade Cyclization for Construction of Oxatricyclic Compounds.

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A highly diastereoselective cascade cyclization reaction has been developed for establishing a series of oxatricyclic compounds using Chan's diene and simple keto alkynal substrates with only 1 mol % of… Click to show full abstract

A highly diastereoselective cascade cyclization reaction has been developed for establishing a series of oxatricyclic compounds using Chan's diene and simple keto alkynal substrates with only 1 mol % of In(OTf)3 as the catalyst in 82-92% yields. The potential utility of this synthetic strategy has been demonstrated in model studies for the construction the core structures of 1α,8α:4α,5α-diepoxy-4,5-dihydroosmitopsin and cortistatin A.

Keywords: otf catalyzed; cascade cyclization; construction; oxatricyclic compounds; catalyzed cascade

Journal Title: Organic letters
Year Published: 2018

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