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Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta.

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Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of… Click to show full abstract

Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC50 value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.

Keywords: minnamide linear; minnamide; linear lipopeptide; marine cyanobacterium; lipopeptide marine; cyanobacterium okeania

Journal Title: Organic letters
Year Published: 2019

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