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An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a… Click to show full abstract
An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a variety of C3-alkoxymethylaed free (N-H) indole in up to 98% yield with excellent regioselectivity. The titled products are useful building blocks in organic synthesis.
Keywords:
via three;
cascade reaction;
three component;
component cascade
Journal Title: Organic letters
Year Published: 2019
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Journal Title: Organic letters
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!