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The development of a novel ( Z)-α,δ-bisboryl-substituted crotylboron reagent is reported. Ni-catalyzed 1,4-diboration of dienylboronate provided the targeted crotylboronate in good yield with high regio- and stereoselectivity. Chemo- and stereoselective… Click to show full abstract
The development of a novel ( Z)-α,δ-bisboryl-substituted crotylboron reagent is reported. Ni-catalyzed 1,4-diboration of dienylboronate provided the targeted crotylboronate in good yield with high regio- and stereoselectivity. Chemo- and stereoselective addition of this crotylboron reagent to aldehydes followed by protection of the resulting secondary hydroxyl group gave TES-protected homoallylic alcohols bearing an alkyl and a vinyl boronate groups with high stereoselectivities.
Journal Title: Organic letters
Year Published: 2019
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