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A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable "side arm" groups have been established, enabling the asymmetrical hydrogenation of unsymmetrical benzophenones with outstanding activity (up… Click to show full abstract
A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable "side arm" groups have been established, enabling the asymmetrical hydrogenation of unsymmetrical benzophenones with outstanding activity (up to 13 000 TON) and excellent enantioselectivity (up to >99% ee). This protocol uses K2CO3 as an industrially desirable base and features a wide substrate scope and functional group tolerance. Moreover, the imine group in the catalyst is crucial for accessing high activities and good enantioselectivities.
Journal Title: Organic letters
Year Published: 2019
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