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An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[ c, e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important… Click to show full abstract
An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[ c, e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5 H-dibenz[ c,e]azepines via two-step reductive amination was also developed.
Keywords:
azepine derivatives;
dibenzo azepine;
asymmetric hydrogenation;
hydrogenation dibenzo
Journal Title: Organic letters
Year Published: 2019
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!