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An efficient aerobic copper(I)-catalyzed oxyamination of β,γ-unsaturated hydrazones has been developed. The methodology provides effective access to dihydropyrazole derivatives in a one-pot process utilizing dioxygen as a sustainable sacrificial oxidant.… Click to show full abstract
An efficient aerobic copper(I)-catalyzed oxyamination of β,γ-unsaturated hydrazones has been developed. The methodology provides effective access to dihydropyrazole derivatives in a one-pot process utilizing dioxygen as a sustainable sacrificial oxidant. Mechanistic studies have been performed and are suggestive of an aerobic manifold via single electron transfer.
Keywords:
oxyamination unsaturated;
hydrazones synthesis;
copper catalyzed;
catalyzed oxyamination;
unsaturated hydrazones
Journal Title: Organic letters
Year Published: 2019
Link to full text (if available)
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Journal Title: Organic letters
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!