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Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to obtain selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve… Click to show full abstract
Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to obtain selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve selective addition of azoles to the proximal or distal carbon of activated allenes depending on the catalyst used, unravelling a gold-platinum bimetallic catalysis approach for the 1,3-double addition of azoles to activated allenes to give 1,3-bisazole derivatives, an important scaffold in medicinal and organometallic chemistry.
Journal Title: Organic letters
Year Published: 2019
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