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Cobalt-Catalyzed Oxidative Annulation of Benzothiophene-[b]-1,1-dioxide through Diastereoselective Double C-H Activation.

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The use of inexpensive base metal catalysis to perform C-H activation is an active field of research in organic synthesis. Described herein is a sustainable cobalt-catalyzed diastereoselective oxidative annulation/double C-H… Click to show full abstract

The use of inexpensive base metal catalysis to perform C-H activation is an active field of research in organic synthesis. Described herein is a sustainable cobalt-catalyzed diastereoselective oxidative annulation/double C-H activation of benzothiophene-[b]-1,1-dioxide with aminoquinolinamides under mild reaction conditions for the synthesis of annulated benzothiophenes.

Keywords: oxidative annulation; benzothiophene dioxide; cobalt catalyzed; double activation; activation

Journal Title: Organic letters
Year Published: 2019

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