A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C(sp)-C(sp2) and C(sp2)═N bonds were… Click to show full abstract
A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C(sp)-C(sp2) and C(sp2)═N bonds were constructed in one pot. This reaction featured in high efficiency, excellent chemoselectivity, and good functional group compatibility. The synthetic utility of this method was also demonstrated.
               
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