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One-Pot Aminoalkylation of Aldehydes: Diastereoselective Synthesis of Vicinal Diamines with Azaarylmethylamines.

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A one-pot synthesis of vicinal diamines with azaarylmethylamines and aldehydes is reported. A diverse array of vicinal diamines could be achieved in up to 92% yield with good to excellent… Click to show full abstract

A one-pot synthesis of vicinal diamines with azaarylmethylamines and aldehydes is reported. A diverse array of vicinal diamines could be achieved in up to 92% yield with good to excellent diastereoselectivities (up to 20:1). The tandem reaction takes place under mild conditions and provides an alternative strategy for the synthesis of vicinal diamines.

Keywords: synthesis vicinal; diamines azaarylmethylamines; vicinal diamines; one pot

Journal Title: Organic letters
Year Published: 2019

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