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Cu-Catalyzed Direct Diversification of 2-(2-Bromophenyl)quinazolin-4(3H)-ones through Orthogonal Reactivity Modulation.

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A modular strategy to obtain three different products from a single substrate was developed. The present methodology unveils new step-economical and cost-efficient routes to access diverse fused quinazolinoquinazolinone derivatives which… Click to show full abstract

A modular strategy to obtain three different products from a single substrate was developed. The present methodology unveils new step-economical and cost-efficient routes to access diverse fused quinazolinoquinazolinone derivatives which are not prevalent in literature. Owing to the importance of quinazolinones in therapeutics, quick access to the arena of these scaffolds could be a valuable addition to the scientific domain of heterocyclic chemistry.

Keywords: bromophenyl quinazolin; ones orthogonal; diversification bromophenyl; quinazolin ones; catalyzed direct; direct diversification

Journal Title: Organic letters
Year Published: 2019

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