The work presented in this report demonstrates that amphiphilic polysaccharide-clasped self-assembly (Amp-SA) with nanometer sizes, encapsulating hydrophobic nanoparticles (NPs) can be generated via electrohydrodynamic spraying. It is observed that the… Click to show full abstract
The work presented in this report demonstrates that amphiphilic polysaccharide-clasped self-assembly (Amp-SA) with nanometer sizes, encapsulating hydrophobic nanoparticles (NPs) can be generated via electrohydrodynamic spraying. It is observed that the formation of hydrophobic NPs-encapsulated Amp-SA is dependent on the surface chemistry of NPs. The citrate-coated magnetic NPs (MNPs-Cit) were also prepared and compared. The hydrophobic magnetic NPs-encapsulated Amp-SA (Amp-SA-M) exhibited around 2.7 ~ 2.8 fold higher values in r2 relaxivity than that of MNPs-Cit. In addition, the resulting Amp-SA-M achieved ~17.2-fold higher values in r2/r1 ratios than MNPs-Cit. The enhanced performances in magnetic transverse (r2) relaxivity and r2/r1 ratio as well as the in vivo behavior of Amp-SA-M suggest the potential of Amp-SA-M as a promising MRI nanoprobe. This approach based on the nature-originated amphiphilic biopolymers may provide a novel insight into electrohydrodynamic techniques that have the ability to create various nanostructures, encapsulating high-quality hydrophobic nanomaterials for applications in diverse biotechnology.
               
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