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The integration of combinational photochemotherapy could achieve a promoted therapeutic performance by eliminating the frustrating side effects of each constitute, yet is still confronted with severe therapeutic resistances that are… Click to show full abstract
The integration of combinational photochemotherapy could achieve a promoted therapeutic performance by eliminating the frustrating side effects of each constitute, yet is still confronted with severe therapeutic resistances that are associated with tumor hypoxia. Herein, we designed a multifunctional gene therapy-mediated photochemotherapy strategy for specifically alleviating the hypoxia-associated therapeutic resistance. The pH-responsive zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (CDHNs) facilitated the effective delivery of therapeutic agents (chlorin e6 (Ce6), doxorubicin (DOX) and HIF-1α siRNA) into tumor for relieving specifically photochemotherapy resistance via sequential activation manners under the guidance of fluorescence imaging. The present all-in-one compact CDHNs system provides a smart and versatile multiply gained therapeutic strategy to activate the specific cellular pathways and is anticipated to boost future cancer diagnosis and post-treatment.
Journal Title: ACS applied materials & interfaces
Year Published: 2020
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