LAUSR

2,6-Lutidine (2,6-LT) is a very important raw material in the chemical industry, but the impurities of 3-picoline (3-PC) and 4-picoline (4-PC) existing in 2,6-LT seriously affect its quality. Considering different molecular sizes of these three compounds, herein, we exploit nonporous adaptive crystals (NACs) of pillararenes as purifying agents for removal of 3-PC and 4-PC in 2,6-LT. We find that per-ethylated pillar[5]arene (EtP5) can selectively adsorb 3-PC and 4-PC, while negligible capture of 2,6-LT is observed, resulting in improvement of the purity of 2,6-LT up to 94.9%. Single-crystal structures indicate that the excellent selectivity originates from the size match and complexation stability differences among different host/guest pairs. After purification, NACs of EtP5 can be easily regenerated and used in the next run without a significant performance degradation.