LAUSR

Phototherapy, containing photothermal and photodynamic therapy, has attracted extensive attention due to its noninvasive nature, low toxicity, and high anticancer efficiency. Charge-separation mechanism of plasmon-induced resonance energy transfer (PIRET), has been increasingly employed to design nanotheranotic agents. Herein, we developed a novel and smart PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into Au@Cu2O nanostructure, which was then assembled with poly(allylamine) (PAH) modified black phosphorus quantum dots (Au@PB@Cu2O@BPQDs/PAH nanocomposites). The hybrid nanosystem exhibited great absorption in NIR region, as well as the ability to self-supply O2 by catalyzing hydrogen peroxide and convert O2 into singlet oxygen (1O2) under 650 nm laser light (0.5 W/cm2) irradiation. In vitro and in vivo assay showed that the generated heat and toxic 1O2 from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of PB modified nanosystem allowed for synergistic therapy with the aid of T1-weighed magnetic resonance imaging (T1-weighted MRI) and photoacoustic imaging (PAI). This study presented a suitable way to fabricate smart PIRET-based nanosystem with enhanced PTT/PDT efficacy and dual-modal imaging functionality. The great biocompatibility and low toxicity ensured their high potential for use in cancer therapy.