LAUSR

The development and application of nano-drug carriers might provide an excellent opportunity for cancer therapy. However, it is still an important challenge to realize the regulation and control of drug loading by analyzing the assembly process of carrier loaded drugs. Herein, shows a "self-contained bioactive nanocarrier" system, which is prepared from ursolic acid, one of very promising biologically active natural products with self-assembly properties. The study decrypt the assembly process of drug-carrier interaction and achieve the regulation of drug loading by controlling the interaction force. This nanocarrier highlights the unique advantages of active natural products in therapeutic efficacy and health benefits. In anti-tumor experiments, the carrier and drug demonstrated synergistic therapeutic efficacy. Furthermore, the nanocarrier is biosafe and capable of reducing the risk of liver damage induced by chemotherapeutics through the upregulation of key antioxidant pathways. Taken together, this "self-contained bioactive nanocarrier" system makes up for the defect that conventional nanocarriers have no therapeutic efficacy and health benefits, and eliminate the trouble of the toxic side effects associated with chemotherapy agents and the additional toxicity caused by long-term use of nanocarriers.