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Tuning of Conformational Dynamics Through Evolution-Based Design Modulates the Catalytic Adaptability of an Extremophilic Kinase

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Conformational flexibility plays a critical role in enzyme function and is a key aspect in transitions from an open to a closed state induced by substrate binding and product release.… Click to show full abstract

Conformational flexibility plays a critical role in enzyme function and is a key aspect in transitions from an open to a closed state induced by substrate binding and product release. Psychrophilic...

Keywords: tuning conformational; conformational dynamics; design modulates; evolution based; dynamics evolution; based design

Journal Title: ACS Catalysis
Year Published: 2020

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