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The Catalytic Reaction Mechanism of the β-Galactocerebrosidase Enzyme Deficient in Krabbe Disease

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Krabbe disease is a neurodegenerative disorder related to misfunction of β-galactocerebrosidase (GALC), a glycosidase that cata-lyzes the cleavage of β-galactosidic bonds in glycosphingolipids. Her... Click to show full abstract

Krabbe disease is a neurodegenerative disorder related to misfunction of β-galactocerebrosidase (GALC), a glycosidase that cata-lyzes the cleavage of β-galactosidic bonds in glycosphingolipids. Her...

Keywords: krabbe; galactocerebrosidase; catalytic reaction; krabbe disease; reaction mechanism

Journal Title: ACS Catalysis
Year Published: 2020

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