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Structure and Dynamics of the Reactive State for the Histidine Methylation Process and Catalytic Mechanism of SETD3: Insights from Quantum Mechanics/Molecular Mechanics Investigation

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The SETD3 enzyme adds a methyl group to Ne2 of His73 in β-actin, and such methylation finetunes actin’s biochemical properties and cellular function. Here, quantum mechanics/molecular mechanics mol... Click to show full abstract

The SETD3 enzyme adds a methyl group to Ne2 of His73 in β-actin, and such methylation finetunes actin’s biochemical properties and cellular function. Here, quantum mechanics/molecular mechanics mol...

Keywords: methylation; molecular mechanics; mechanics molecular; setd3; quantum mechanics; mechanics

Journal Title: ACS Catalysis
Year Published: 2020

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