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Insights into the Catalytic Mechanism of Domains CD1 and CD2 in Histone Deacetylase 6 from Quantum Calculations

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The histone deacetylase 6 enzyme, HDAC6, is a metalloprotein with multiple pathophysiological roles and, as such, is the subject of intense research and drug discovery efforts. Different from the H... Click to show full abstract

The histone deacetylase 6 enzyme, HDAC6, is a metalloprotein with multiple pathophysiological roles and, as such, is the subject of intense research and drug discovery efforts. Different from the H...

Keywords: insights catalytic; histone deacetylase; mechanism domains; histone; catalytic mechanism

Journal Title: ACS Catalysis
Year Published: 2021

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