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Nature of Irreversible Inhibition of Human 20S Proteasome by Salinosporamide A. The Critical Role of Lys–Asp Dyad Revealed from Electrostatic Effects Analysis

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20S proteasome is the enzymatic core engine involved in the processes of cellular protein regulation, thus becoming a promising target inter alia in the therapy of many diseases. In this… Click to show full abstract

20S proteasome is the enzymatic core engine involved in the processes of cellular protein regulation, thus becoming a promising target inter alia in the therapy of many diseases. In this work, the ...

Keywords: nature irreversible; proteasome salinosporamide; inhibition human; 20s proteasome; human 20s; irreversible inhibition

Journal Title: ACS Catalysis
Year Published: 2021

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