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Controlling Stereopreferences of Carbonyl Reductases for Enantioselective Synthesis of Atorvastatin Precursor

Carbonyl reductase (CR)-catalyzed asymmetric reduction offers an approach for producing t-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate ((3R,5R)-1b), which serves as a key building block in atorvastatin... Click to show full abstract

Carbonyl reductase (CR)-catalyzed asymmetric reduction offers an approach for producing t-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate ((3R,5R)-1b), which serves as a key building block in atorvastatin...

Keywords: carbonyl reductases; controlling stereopreferences; stereopreferences carbonyl; enantioselective synthesis; reductases enantioselective; atorvastatin

Journal Title: ACS Catalysis
Year Published: 2021

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