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A rhodium-catalyzed azide–alkyne cycloaddition of internal ynamides is described. The reaction could be performed in a wide range of solvents, including aqueous media, under mild conditions without careful exclusion of… Click to show full abstract
A rhodium-catalyzed azide–alkyne cycloaddition of internal ynamides is described. The reaction could be performed in a wide range of solvents, including aqueous media, under mild conditions without careful exclusion of air and moisture, giving a variety of 5-amino-triazoles as a single regioisomer. The mechanism of regioselective cycloaddition was rationalized by means of density functional theory calculations.
Keywords:
cycloaddition;
cycloaddition internal;
rhodium catalyzed;
alkyne cycloaddition;
azide alkyne;
catalyzed azide
Journal Title: ACS Catalysis
Year Published: 2017
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Journal Title: ACS Catalysis
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!