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A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C–C bond through a radical process is described. The sequence comprises an initial in… Click to show full abstract
A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C–C bond through a radical process is described. The sequence comprises an initial in situ generation of a putative iron hydride followed by a hydrogen atom transfer to an alkene, a coupling with a hydrazone, and a final reduction of the nitrogen-centered radical. Hydrogenation of the obtained hydrazines renders amines, including valuable tert-alkyl amines.
Keywords:
coupling alkenes;
iron;
hydrogen atom;
atom transfer
Journal Title: ACS Catalysis
Year Published: 2018
Link to full text (if available)
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Journal Title: ACS Catalysis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!