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We report a highly efficient and chemoselective Minisci-type alkylation reaction of N-heteroarenes with alkanes under the reagent control of a hypervalent iodine oxidant PFBI-OH. In addition to the high reactivity,… Click to show full abstract
We report a highly efficient and chemoselective Minisci-type alkylation reaction of N-heteroarenes with alkanes under the reagent control of a hypervalent iodine oxidant PFBI-OH. In addition to the high reactivity, PFBI-OH demonstrated a high steric sensitivity for H abstraction of alkanes. This reaction is selective for more sterically accessible secondary C–H bonds over weaker tertiary C–H bonds. High selectivity toward penultimate methylene groups was observed for a wide range of acyclic alkanes.
Keywords:
heteroarenes alkanes;
minisci type;
methylene;
selectivity;
type alkylation
Journal Title: ACS Catalysis
Year Published: 2018
Link to full text (if available)
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Journal Title: ACS Catalysis
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!