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A palladium-catalyzed stereospecific alkylation of allylamines with primary and secondary alkyl iodides is described. Isoquinoline-1-carboxamide (IQA) acts as directing group to generate multisubstituted olefin products in cis configuration in moderate… Click to show full abstract
A palladium-catalyzed stereospecific alkylation of allylamines with primary and secondary alkyl iodides is described. Isoquinoline-1-carboxamide (IQA) acts as directing group to generate multisubstituted olefin products in cis configuration in moderate to good yields. Mechanistic studies suggest that alkenyl C–H bond activation is the rate-determining step.
Keywords:
alkenyl bond;
catalyzed stereospecific;
palladium catalyzed;
alkylation allylamines;
alkyl iodides
Journal Title: ACS Catalysis
Year Published: 2019
Link to full text (if available)
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Journal Title: ACS Catalysis
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!