LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Stretching Peptides’ Potential to Target Protein–Protein Interactions

Photo from wikipedia

Protein−protein interactions (PPIs) are key biological targets for next-generation drug discovery. Peptide-derived molecules are ideal for targeting PPIs because they can closely mimic the binding surfaces presented by the proteins… Click to show full abstract

Protein−protein interactions (PPIs) are key biological targets for next-generation drug discovery. Peptide-derived molecules are ideal for targeting PPIs because they can closely mimic the binding surfaces presented by the proteins in the PPI. Conformational control represents a major challenge in advancing peptides as PPI modulators for pharmaceutical development. In this issue of ACS Central Science, Philip Dawson and co-workers report an efficient approach to access “stretched” peptides, namely, those with an enforced geometry resembling that of a β-sheet. They accomplish this by installing a strained diyne-containing macrocycle and establishing the role of various modifications to the macrocycle’s structure in altering both the conformation of the peptide backbone and the antibiotic activity.

Keywords: protein protein; peptides potential; stretching peptides; protein interactions; potential target; protein

Journal Title: ACS Central Science
Year Published: 2023

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.