LAUSR

Nitric oxide (NO) is a versatile gasotransmitter contribute in a range of physiological and pathological mechanims depending on its cellular levels. Appropriate concentration of NO is essentially required for the cellular physiology however its increased level triggers the pathological mechanisms like altered cellular redox regulation, functional impairment of mitochondrionalong with modifications in cellular proteins and DNA. Its increased levels also exhibit the post translational modifications in protein through S-nitrosylation of theirthiol amino acids which critically affect the cellular physiology. Along with such modifications NO could also nitrosylate the endoplasmic reticulum (ER)-membrane located sensors of ER stress which subsequently affect the cellular protein degradation capacity and lead to aggregation of misfolded/unfolded proteins. Since protein aggregation is one of the pathological hallmarks of neurodegenerative disease NO should be taken in to account during development of diseases therapies. In this review we shed light on the diverse role of NO in both cellular physiology and pathology and discussed its involvement in various pathological events in context of neurodegenerative diseases.