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An efficient one-pot multi-component reaction for the synthesis of novel tetrasubstituted hexahydroimidazo[1,2-a]pyridines starting from readily available cinnamaldehydes, ethylenediamines and 1,3-dicarbonyl compounds catalyzed by AcOH is de-scribed. Two new cycles and… Click to show full abstract
An efficient one-pot multi-component reaction for the synthesis of novel tetrasubstituted hexahydroimidazo[1,2-a]pyridines starting from readily available cinnamaldehydes, ethylenediamines and 1,3-dicarbonyl compounds catalyzed by AcOH is de-scribed. Two new cycles and four new bonds are constructed with all reactants being efficiently utilized in this transformation. The products could be obtained in 1~3 h under ambient conditions exclusively as a single isomer (trans). Single crystal X-ray analysis confirmed the trans derivative as the only isomer.
Journal Title: ACS combinatorial science
Year Published: 2020
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